Sunday, March 6, 2011

Site selected (targeted) drug delivery for cancer treatments. [My first post on UCF Research Group's blog]


Commonly used drug delivery methods such as ingestion and intravenous injection will soon be a part of medical history. These methods mentioned above are somehow ineffective, dispersing medications by means of our systematic blood circulation and only a small portion of the medication reaches the affected area. The recent advances of science and engineering in the medical field have helped design newer, more effective methods used for delivering drugs in the human body.  Such as site selective or “targeted” drug delivery, this method seeks to increase the concentration of medication in a selected area. Thus reducing the concentration of medications in other parts of the system. Increasing the effect of the medication while decreasing its side effects. Targeted drug delivery can be used to treat many conditions and diseases, such as coronary, pancreas, and hard to reach areas inside our system. However the most important application at the moment is treating cancerous tumors. In cancer treatment the current focus is providing therapeutic concentrations of anticancer agents at the site of action and sparing the normal (healthy) tissues [1] a great advantage over the common cancer treatments consisting of radiation which is later dispersed through the body. Cancer therapies using targeted drug delivery are more effective in delivering the medication to the affected area and they keep the concentration of the medication in the tumor. Therapies using targeted drug delivery consist of coupling a monoclonal antibody against the receptor and/or by coupling to a high affinity ligand (such as a protein or a lipid).[2] The extracellular calcium-sensing receptor (CaR) is also studied as a change in the concentration of Ca+2 ions causes the cell to become differentiate uncontrollably, so controlling the CaR could potentially serve a supportive function in cancer management. [3] 


The original post with the references/cited work can be found at the following link. UCF Research Group - University of Puerto Rico, Mayagüez Campus
Jeromi G. López

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